This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Aliases：    TDT    

Entrez GeneID：    1791    

Swissprot ：   P04053     

WB Predicted band size ：   58.5kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human,Rat    

Immunogen：    Purified recombinant fragment of human DNTT (AA: 52-192) expressed in E. Coli.    

WB    1/500 - 1/2000    

FCM    1/200 - 1/400    

ELISA    1/10000