CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases：    TBRS; DNMT3A2; M.HsaIIIA    

Entrez GeneID：    1788    

Swissprot：    Q9Y6K1     

WB Predicted band size：    102kDa    

Host/Isotype：    Mouse IgG2a    

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human DNMT3A (AA: 46-180) expressed in E. Coli.    

IHC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000