Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.
Aliases： Desmin
Entrez GeneID： 1674
Swissprot： P17661
WB Predicted band size： 54kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse,Rat,Rabbit,Monkey
Immunogen： Purified recombinant fragment of Desmin expressed in E. Coli.
WeChat
