Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.

Aliases：    MGC117393; CSK    

Entrez GeneID：    1445    

Swissprot：    P41240    

WB Predicted band size：    50kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human,Mouse,Monkey,Rat    

Immunogen：    Purified recombinant fragment of human CSK expressed in E. Coli.    

WB    1/500 - 1/2000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000