This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Aliases： CRKII
Entrez GeneID ： 1398
Swissprot ： P46108
WB Predicted band size ： 42kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human CRK expressed in E. Coli.
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