This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

Aliases ：   CLP    

Entrez GeneID ：   23406    

Swissprot：    Q14019    

WB Predicted band size：    16kDa    

Host/Isotype    Mouse IgG1    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human COTL1 expressed in E. Coli.    

IHC    1/200 - 1/1000    

ELISA    1/10000