This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Aliases:    FCAR; FcalphaRI; CTB-61M7.2    

Entrez GeneID:    2204    

Swissprot:   P24071    

WB Predicted band size:    32.3kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen :   Purified recombinant fragment of human CD89 (AA: extra 22-227) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000