The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene.
Aliases： S5.7; CVID6; TAPA1; TSPAN28
Entrez GeneID ： 975
Swissprot： P60033
WB Predicted band size： 25.8kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human, Rat
Immunogen： Purified recombinant fragment of human CD81 (AA: 113-201) expressed in E. Coli.
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