The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases：    ICAM3; CDW50; ICAM-R    

Entrez GeneID：    3385    

Swissprot ：   P32942    

WB Predicted band size：    59.5kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human CD50 (AA: extra 30-203) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000