The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency.

Aliases:    T3G; IMD17; CD3-GAMMA    

Entrez GeneID:    917    

Swissprot :   P09693    

WB Predicted band size:    20.5kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity :   Human    

Immunogen :   Purified recombinant fragment of human CD3G (AA: extra 23-116) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000