The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
Aliases： T3D; IMD19; CD3-DELTA
Entrez GeneID ： 915
Swissprot ： P04234
WB Predicted band size ： 18.9kDa
Host/Isotype： Mouse IgG2b
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human CD3D (AA: 127-171) expressed in E. Coli.
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