This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
Aliases : CLEC7A; BGR; CANDF4; SCARE2; DECTIN1; CLECSF12
Entrez GeneID: 64581
Swissprot : Q9BXN2
WB Predicted band size : 27.6kDa
Host/Isotype : Mouse IgG1
Species Reactivity: Human
Immunogen : Purified recombinant fragment of human CD369 (AA: extra 66-247) expressed in E. Coli.
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