The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Aliases :   SLAMF6; KALI; NTBA; KALIb; Ly108; NTB-A; SF2000    

Entrez GeneID:    114836    

Swissprot :   Q96DU3    

WB Predicted band size :   37.4kDa    

Host/Isotype:    Mouse IgG1     

Species Reactivity:    Human    

Immunogen :   Purified recombinant fragment of human CD352 (AA: extra 22-226) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000