The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Aliases:    JAG1; AGS; AHD; AWS; HJ1; AGS1; JAGL1    

Entrez GeneID :   182    

Swissprot :   P78504    

WB Predicted band size :   133.8kDa    

Host/Isotype :   Mouse IgG1     

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human CD339 (AA: extra 47-212) expressed in E. Coli.    

WB    1/500 - 1/2000    

FCM    1/200 - 1/400    

ELISA    1/10000