The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
Aliases: MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; ABCG2; GOUT1; MXR-1; CDw338; UAQTL1; EST157481
Entrez GeneID : 9429
Swissprot : Q9UNQ0
WB Predicted band size: 75kDa
Host/Isotype : Mouse IgG2b
Species Reactivity : Human, Mouse
Immunogen: Purified recombinant fragment of human CD338 (AA: extra mix) expressed in E. Coli.
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