Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Aliases ： F11R;JAM; KAT; JAM1; JAMA; JCAM; PAM-1
Entrez GeneID ： 50848
Swissprot ： Q9Y624
WB Predicted band size： 32.6kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human CD321 (AA: extra 28-238) expressed in E. Coli.
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