The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
Aliases： TLR1; TIL; rsc786; TIL. LPRS5
Entrez GeneID： 7096
Swissprot ： Q15399
WB Predicted band size： 90.2kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human CD281 (AA: extra 172-425) expressed in E. Coli.
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