The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Aliases ： T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA; CD247
Entrez GeneID ： 919
Swissprot： P20963
WB Predicted band size： 18kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human CD247 expressed in E. Coli.
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