The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
Aliases： CLEC4K
Entrez GeneID： 50489
Swissprot ： Q9UJ71
WB Predicted band size： 36.7kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human CD207 (AA: extra 155-328) expressed in E. Coli.
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