This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described.

Aliases：    FASLG; APTL; FASL; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1    

Entrez GeneID：    356    

Swissprot：    P48023    

WB Predicted band size：    31.5kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity ：   Human    

Immunogen ：   Purified recombinant fragment of human CD178 (AA: extra 103-281) expressed in E. Coli.    

IF/ICC    1/50 - 1/200    

FCM    1/200 - 1/400    

ELISA    1/10000