The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.
Aliases： SIRPB1; SIRP-BETA-1
Entrez GeneID ： 10326
Swissprot ： O00241
WB Predicted band size ： 43.2kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human
Immunogen； Purified recombinant fragment of human CD172b (AA: extra 72-309) expressed in E. Coli.
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