This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Aliases :   SIGLEC5; OBBP2; CD33L2; OB-BP2; SIGLEC-5    

Entrez GeneID :   8778    

Swissprot :   O15389     

WB Predicted band size:    60.7kDa    

Host/Isotype :   Mouse IgG2a    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human CD170 (AA: extra 17-230) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000