This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined.

Aliases :   SIGLEC1; SN; SIGLEC-1; dJ1009E24.1    

Entrez GeneID:    6614    

Swissprot :   Q9BZZ2    

WB Predicted band size:    182.6kDa    

Host/Isotype:    Mouse IgG2a    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human CD169 (AA: extra 20-197) expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000