The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.
Aliases： GP27; MER2; RAPH; SFA1; PETA-3; TSPAN24
Entrez GeneID ： 977
Swissprot： P48509
WB Predicted band size ： 28.3kDa
Host/Isotype ： Mouse IgG2a
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human CD151 (AA: extra 113-221) expressed in E. Coli.
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