The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
Aliases： PTPRJ; DEP1; SCC1; HPTPeta; R-PTP-ETA
Entrez GeneID： 5795
Swissprot： Q12913
WB Predicted band size： 146kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human CD148 (AA: extra 36-210) expressed in E. Coli.
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