The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Aliases ：   TNFRSF9; ILA; 4-1BB; CDw137    

Entrez GeneID：    3604    

Swissprot：    Q07011    

WB Predicted band size：   27.9kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human CD137 (AA: 214-255) expressed in E. Coli.    

WB    1/500 - 1/2000    

FCM    1/200-1/400    

ELISA    1/10000