The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

Aliases：    TNFRSF4; OX40; ACT35; IMD16; TXGP1L    

Entrez GeneID：    7293    

Swissprot ：   P43489    

WB Predicted band size：    29.3kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity ：   Human    

Immunogen ：   Purified recombinant fragment of human CD134 (AA: extra 29-214) expressed in E. Coli.    

IHC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000